Youthful Plasticity Restored to Brains of Adult Mice

Brain Imaging

(Science Bulletin) – Like much of the rest of the body, the brain loses flexibility with age, impacting the ability to learn, remember, and adapt. Now, scientists at University of Utah Health report they can rejuvenate the plasticity of the mouse brain, specifically in the visual cortex, increasing its ability to change in response to experience.

Manipulating a single gene triggers the shift, revealing it as a potential target for new treatments that could recover the brain’s youthful potential. The research was published online in the Proceedings of the National Academy of Sciences (PNAS) on August 8.

“It’s exciting because it suggests that by just manipulating one gene in adult brains, we can boost brain plasticity,” says lead investigator Jason Shepherd, Ph.D., Associate Professor of Neurobiology and Anatomy at University of Utah Health.

“This has implications for potentially reducing normal cognitive decline with aging, or boosting recovery from brain injury after stroke or traumatic brain injury,” he says. Additional research will need to be done to determine whether plasticity in humans and mice is regulated in the same way. CONTINUE